Ethylenediamine → 3,5-diamino-N-[2-[[2-[(2-aminoethyl)amino]2-oxoethyl]amino]ethyl]-6-chloropyrazinecarboxamide

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Reaction Steps

A solution of 7.45 g (24.6 mmol) of N-[2-[[(3,5-diamino-6-chloropyrazinyl)carbonyl]amino]ethyl]glycine methyl ester and 22.48 ml (373.9 mmol) of ethylenediamine was stirred at ambient temperature for two days. The excess diamine was evaporated. There was obtained 8.14 g (24.6 mmol, 100%) of 3,5-diamino-N-[2-[[2-[(2-aminoethyl)amino]2-oxoethyl]amino]ethyl]-6-chloropyrazinecarboxamide as a yellow solid: Rf=0.28, Solvent System A.

Provenance & Evidence