Trimethylsilyl iodide → HCID 67887669, compound

HRID 1164860Notes

Reaction equation

HRID 1164860 reaction equation
[CH3:1][O:2][C:3]([C@H:5]1[CH2:10][C@@H:9]([CH2:11][P:12]([O:16]C)([O:14]C)=[O:13])[CH2:8][CH2:7][N:6]1[C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])=[O:4].C[Si](I)(C)C>C(Cl)Cl>[CH3:1][O:2][C:3]([C@H:5]1[CH2:10][C@@H:9]([CH2:11][P:12]([OH:16])([OH:14])=[O:13])[CH2:8][CH2:7][N:6]1[C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])=[O:4]

Participants

4

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 86743736HCID 86743736, compound

Product 1

HCID 67887669HCID 67887669, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 600 mg of cis-1-benzyloxycarbonyl-4-dimethylphosphonomethyl-2-piperidinecarboxylic acid methyl ester in 10 ml of methylene chloride is treated with 538 mg of trimethylsilyl iodide at room temperature to yield cis 1-benzyloxycarbonyl-4-phosphonomethyl-2-piperidine-carboxylic acid methyl ester as an oil.

Sources & evidence

ORD record
ord-e74969a7811c47758c997f0fdb128012
Source dataset
uspto-grants-1990_03
Patent number
US04906621

Reaction notes

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