Cyclopropylamine → HCID 70358762, compound

HRID 1164916Notes

Reaction equation

HRID 1164916 reaction equation
Cl[C:2]1([S:8](Cl)(=[O:10])=[O:9])[NH:6][C:5]([Cl:7])=[CH:4][S:3]1.[CH:12]1([NH2:15])[CH2:14][CH2:13]1>C1(C)C=CC=CC=1.C(O)C>[CH:12]1([N:15]([NH:15][CH:12]2[CH2:14][CH2:13]2)[S:8]([C:2]2[S:3][CH:4]=[C:5]([Cl:7])[N:6]=2)(=[O:10])=[O:9])[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 22164315HCID 22164315, compound

Product 1

HCID 70358762HCID 70358762, compound

Reagents, catalysts & solvents 1

HCID 21863594Toluene ethanolSolvent

Procedure

In analogy to Example 13, the N-cyclopropyl-2-N-cyclopropylamino-4-chlorothiazolesulphonamide was prepared by reacting 2,4-dichlorothiazole-sulphonyl chloride from Example 1 with cyclopropylamine. Following chromatography on silica gel using toluene/ethanol (5:1) as the eluent, 15.0 g of product were obtained (51% of the theoretical yield), m.p. 176°-177° C.

Sources & evidence

ORD record
ord-3a90f86dd238453087dd253a93b2b49a
Source dataset
uspto-grants-1990_03
Patent number
US04906650

Reaction notes

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