Potassium thiocyanate → HCID 53916869, compound

HRID 1164931Notes

Reaction equation

HRID 1164931 reaction equation
[C:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][CH2:10][CH2:11][S:12][CH2:13][CH2:14]Br)=[C:6]([CH2:18][CH2:19][CH3:20])[C:5]=1[OH:21])(=[O:3])[CH3:2].[S-:22][C:23]#[N:24].[K+]>CC(C)=O>[C:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][CH2:10][CH2:11][S:12][CH2:13][CH2:14][S:22][C:23]#[N:24])=[C:6]([CH2:18][CH2:19][CH3:20])[C:5]=1[OH:21])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 13885752HCID 13885752, compound

Product 1

HCID 53916869HCID 53916869, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

1.0 g. (2.8 mMole) S-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propyl]-2-mercaptoethyl bromide and 5.0 g. potassium thiocyanate are heated to reflux for 2 hours in 25 ml. acetone. Subsequently, the precipitate is filtered off with suction, the solution is evaporated and the residue is stirred with diethyl ether. After evaporating the diethyl ether, there is obtained 0.7 g. (71% of theory) of the title compound in the form of an oil.

Workup

  1. temperatureto reflux for 2 hours in 25 ml
  2. filtrationSubsequently, the precipitate is filtered off with suction
  3. customthe solution is evaporated
  4. customAfter evaporating the diethyl ether
  5. customthere is obtained 0.7 g

Sources & evidence

ORD record
ord-9b92a8ab9d9b45c49c8b38e140892aaf
Source dataset
uspto-grants-1990_03
Patent number
US04906666

Reaction notes

Loading…