反应详情

Combine 10.7 g (0.1 mol) of benzenemethanamine and 17.7 g (0.1 mol) of (2-bromoethyl)cyclopentane in 100 mL of acetonitrile. Heat the mixture to reflux and follow the progress of the reaction by thin-layer chromatography on silica gel. At the completion of the reaction remove the solvent in vacuo and add 100 mL of saturated sodium bicarbonate solution. Extract the aqueous mixture with three 100 mL portions of diethyl ether. Dry the combined extracts over anhydrous sodium sulfate. Filter the drying agent and remove the solvent in vacuo to obtain the title compound.

1. temperatureHeat the mixture
2. temperatureto reflux
3. customthe progress of the reaction by thin-layer chromatography on silica gel
4. customAt the completion of the reaction remove the solvent in vacuo
5. additionadd 100 mL of saturated sodium bicarbonate solution
6. extractionExtract the aqueous mixture with three 100 mL portions of diethyl ether
7. dry with materialDry the combined extracts over anhydrous sodium sulfate
8. filtrationFilter the drying agent
9. customremove the solvent in vacuo