反应详情

Hydrogenate a solution of 8.5 g (29.4 mmol) of N,N-diethyl-3-(4-nitrophenoxy)propanamine hydrochloride in 100 mL of methanol over 0.92 g of 10% palladium on carbon catalyst at 40-45 psi at room temperature. When hydrogen uptake ceases remove the catalyst by filtration and add 5 mL of concentrated hydrochloric acid. Remove the solvent in vacuo. Recrystallize the residue from ethanol to obtain the title compound.

1. customat room temperature
2. customremove the catalyst
3. filtrationby filtration
4. additionadd 5 mL of concentrated hydrochloric acid
5. customRemove the solvent in vacuo
6. customRecrystallize the residue from ethanol