Stannous chloride dihydrate → HCID 53686295, compound

Participants

Reaction Steps

To 5.00 g (13.6 mmol) of 1-[2-[2-(diethylamino)ethoxy]-5-nitrophenyl]-3-phenyl-2-propen-1-one in 50 mL of ethanol add 9.20 g (40.8 mmol) of tin(II) chloride dihydrate and heat the mixture to reflux with stirring for two hours. After cooling remove the solvent in vacuo. Add water and adjust the pH to 12 with potassium hydroxide. Add ethyl acetate and filter the mixture through celite. Separate the layers of the filtrate and extract the aqueous layer twice with ethyl acetate. Wash the combined organic layers with water, saturated sodium chloride solution, and dry over anhydrous sodium sulfate. Remove the solvent in vacuD to provide the title compound.

Provenance & Evidence