Diethyl Pyrocarbonate → HCID 14649921, compound

Participants

Reaction Steps

A 1 g quantity of 2,6-di-tert-butyl-4-(2-carboxyphenylamino)phenol (Compound 25) was dissolved in 20 ml of DMF. To the solution were added with ice-cooling 340 mg of benzylamine and 570 mg of DEPC and then added a solution of 330 mg of triethylamine in 5 ml of DMF over 20 minutes. Then the reaction mixture was stirred at room temperature for 20 hours, and then poured into water, and extracted with ethyl acetate. The organic layer was washed with water, dried over MgSO4 and concentrated to give a crude product which was purified by silica gel column chromatography (eluent: diethyl ether-hexane=1:10→1:5), giving 1.1 g of the title compound as white crystals.

Provenance & Evidence