Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chlorobenzylamine → N-((2-chlorophenyl)methyl)thiophene-2-ethylamine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chlorobenzylamine | HCID 66648 | — |
| 반응물 | 2-Thiopheneethanol | HCID 79400 | — |
| 반응물 | 2-Thiopheneethanol tosylate | HCID 3682034 | — |
| 생성물 | N-((2-chlorophenyl)methyl)thiophene-2-ethylamine hydrochloride | HCID 6454011 | — |
반응 단계
Another synthetic route involved preparation of a 2-(2-thienyl)ethanol, its conversion to 2-(2-thienyl)ethyl paratoluene sulfonate and benzylation with o-chlorobenzylamine to give N-(2-chloro-benzyl)-2-(2-thienyl)ethylamine hydrochloride, which is cyclized to give ticlopidine free base, as described by Braye in U.S. Pat. No. 4,127,580.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04906756 |
| 출처 데이터셋 | uspto-grants-1990_03 |
| ORD ID | ord-9821706cd9774fa6b5013d08f0448b02 |
| 출처 메모 | uspto-grants-1990_03 |