Thionyl Chloride → 1-methyl-1H-indazole-3-carbonyl chloride

HRID 1165080Notes

Reaction equation

HRID 1165080 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([OH:13])=O)=[N:3]1.S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([Cl:16])=[O:13])=[N:3]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 6891051H-Indazole-3-carboxylic acid, 1-methyl-

Product 1

HCID 70220551-methyl-1H-indazole-3-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A stirred mixture of 1-methyl-3-indazolylcarboxylic acid (0.31 g), thionyl chloride (2 ml) and chloroform (10 ml) was refluxed for 2 hours and the solvent was evaporated to give a residue of 1-methyl-3-indazolylcarbonyl chloride.

Workup

  1. temperaturewas refluxed for 2 hours
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-67b6ea987cec4a10bcba73a40a00b0aa
Source dataset
uspto-grants-1990_03
Patent number
US04906755

Reaction notes

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