Hydrochloric Acid → HCID 19863839, compound

Participants

Reaction Steps

3-(3,7,11,15-Tetramethyl-2-hexadecenyl)-1,2-benzenediol (1.00 g; 2.57 mmole) and conc. hydrochloric acid (2.0 ml) in 10 ml of methanol were heated under reflux for 4 hours, then the reaction solution was poured into 100 ml of water and was extracted twice with 50 ml of isopropyl ether. The extract was washed twice with 100 ml of water and once with 100 ml of saturated aqueous solution of sodium chloride, followed by drying it over anhydrous magnesium sulfate, distilling off the solvent and subjecting the resulting residue to silica gel column chromatography. Thus, 790 mg of the title compound was recovered from the fractions eluted through the column with hexane-ethyl acetate (30:1). Yield=79%.

Provenance & Evidence