HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-Hydroxy-N-(2-phenylethyl)benzenepropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | Trisodium Phosphate | HCID 24243 | — |
| Reactant | N-Succinimidyl-3-(4-hydroxyphenyl)propionate | HCID 99557 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Hydroxy-N-(2-phenylethyl)benzenepropanamide | HCID 568882 | 75% |
Reaction Steps
β-Phenylethylamine is derivatized with Bolton-Hunter reagent as follows. β-Phenylethylamine and Bolton-Hunter reagent were mixed in equimolar quantities in a 1:1 solution of methanol and sodium phosphate buffer (1M, pH 8). After 30 minutes, an excess of water was added. A crystalline solid was collected, washed with water and dried in vacuo giving 1-[3-(4-hydroxyphenyl)-propionylamino]-2-(phenyl) ethane in 75% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04908322 |
| Source dataset | uspto-grants-1990_03 |
| ORD ID | ord-abbc806d550649e5968c8b049bf8ce29 |
| Source note | uspto-grants-1990_03 |