Sodium cyanoborohydride → HCID 19862543, compound

Participants

Reaction Steps

0.9 g of 1-(4-hydroxy-3,5-di-tert.-butylbenzylideneamino)imidazole are suspended in 10 ml of glacial acetic acid and treated with 1.61 g of sodium cyanoborohydride, whereby a solution results. The solution is stirred at room temperature overnight and then evaporated in a vacuum. The residue is treated with 10 ml of water, neutralized (pH=7) with ice-cold saturated sodium bicarbonate solution and extracted three times with 30 ml of methylene chloride each time. The combined organic phases are dried over sodium sulfate, filtered and evaporated in a vacuum. The residue is crystallized with ehter. The product is removed by filtration and reprecipitated from ethanol/water. There is obtained 1-(4-hydroxy-3,5-di-tert.-butylbenzylamino)imidazole of m.p. 171°-174°.

Provenance & Evidence