Sodium cyanoborohydride → HCID 56613324, compound

Participants

Reaction Steps

1.04 g of 1-(4-hydroxy-3,5-di-tert.-butylbenzylideneamino)-2-methylmercaptoimidazole are dissolved in 20 ml of glacial acetic acid and treated portionwise within 30 minutes with 0.43 g of 90% sodium cyanoborohydride. The reaction mixture is stirred at room temperature overnight, whereupon the solvent is removed by evaporation in a vacuum and the residue is taken up with 20 ml of water. Saturated sodium carbonate solution is added up to an alkaline reaction and the mixture is extracted three times with 15 ml of methylene chloride each time. The combined organic phases are dried over sodium sulfate, filtered and evaporated. The residue is recrystallized from methanol/water and there is obtained 1-(4-hydroxy-3,5-di-tert.-butylbenzylamino)-2-methylmercaptoimidazole of m.p. 110°-113°.

Provenance & Evidence