Phosphoric Acid → HCID 19862586, compound

Participants

Reaction Steps

A solution of 4.0 g of the resultant 3-(ethoxycarbonylmethylaminocarbonyloxy)-1-(3-ethoxypropyl)-2-methyl-4(1H)-pyridinone hydrochloride, which melts at 92°-93° C. and is contaminated with a small amount of triethylamine hydrochloride, in 40 ml of water is adjusted to pH 2.5 with phosphoric acid, saturated with sodium chloride, and extracted with methylene chloride. The residue is recrystallised from a 95:5 mixture of ethyl acetate and methylene chloride, giving 3-(ethoxycarbonylmethylaminocarbonyloxy)-1-(3-ethoxypropyl)-2-methyl-4(1H)-pyridinone, which melts at 84°-85° C.

Provenance & Evidence