Hydrochloric Acid → HCID 19862591, compound

Participants

Reaction Steps

The amorphous 3-benzyloxy-1-(3-ethoxypropyl)-2-methyl-4(1H)-pyridinone so obtained is taken up in 100 ml of concentrated aqueous hydrochloric acid and refluxed for 3 minutes. The solution so obtained is diluted with isopropanol and evaporated to dryness. The residue is crystallised from isopropanol and washed with ethyl acetate, affording 1-(3-ethoxypropyl)-3-hydroxy-2-methyl-4(1H)-pyridinone hydrochloride which melts at 130°-131° C.

Provenance & Evidence