HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Iodophenyl)piperidine → HCID 19862673, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Iodophenyl)piperidine | HCID 13203609 | — |
| Reactant | 6-[(Prop-2-yn-1-yl)oxy]hexan-1-ol | HCID 20071434 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Diethylamine | HCID 8021 | — |
| Product | HCID 19862673 | HCID 19862673 | 72.8% |
Reaction Steps
A mixture of 1-(4-iodophenyl)piperidine (1.5 g), 6-[(2-propynyl)oxy]-1-hexanol (820 mg), BTPC (35 mg) and copper (I) iodide (20 mg) in diethylamine (30 ml) under nitrogen, was stired at room temperature overnight. The solvent was evaporated and the residue was partitioned between EA (50 ml) and 8% aqueous sodium bicarbonate (50 ml). The organic layer was washed with water and brine, dried and concentrated to a dark oil which was purified by FCC eluting with ER to give the title compound as an orange oil (1.2 g), t.l.c. (ER) Rf 0.70.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04908386 |
| Source dataset | uspto-grants-1990_03 |
| ORD ID | ord-a6e996483bdc47e38eddaf8514fe11a6 |
| Source note | uspto-grants-1990_03 |