HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroiodobenzene → 4-(4-Fluorophenyl)but-3-yn-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroiodobenzene | HCID 9605 | — |
| Reactant | 3-Butyn-1-OL | HCID 13566 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Diethylamine | HCID 8021 | — |
| Product | 4-(4-Fluorophenyl)but-3-yn-1-ol | HCID 12478440 | 34.2% |
Reaction Steps
Copper (I) iodide was added to a stirred solution of 1-fluoro-4-iodobenzene (11.09 g), 3-butyn-1-ol (3.5 g), and BTPC (100 g) in diethylamine (70 ml) and the mixture stirred under nitrogen for 16 h. The mixture was evaporated in vacuo and purified by FCC on eluting with H - EA (2:1) gave the title compound as a yellow solid (2.8 g). T.l.c. (H - EA 2:1) RF 0.20.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04908386 |
| Source dataset | uspto-grants-1990_03 |
| ORD ID | ord-25934e96c9a34d6b9c41560041e03173 |
| Source note | uspto-grants-1990_03 |