Sodium Hydroxide → HCID 19862672, compound

Participants

Reaction Steps

Sodium borohydride (1.25 g) was added in portions to a stirred solution of 2-bromo-1-[3-fluoro-4-(phenylmethoxy)phenyl]ethanone (16.6 g) in dioxan (100 ml) and methanol (100 ml) at 0°. After 0.5 h a solution of sodium hydroxide (4.0 g) in water (20 ml) was added and the mixture stirred for a further 1 h at 0°. Water was added and the mixture extracted with EA. The extracts were dried and evaporated to give the title compound as a colourless oil (12.6 g) which partially solidified on standing, t.l.c. (PE-EA 6:4) Rf 0.40.

Provenance & Evidence