反应详情

To 5 g of 3-(2-aminothiazol-4-ylmethylthio)propionitrile were added 11 g of amidinopyrazole hydrochloride and 15 ml of 1,3-dimethyl-2- imidazolidinone and the mixture was heated to 110°-120° C. for 4 hours. After cooling, 120 ml of water was added to the reaction mixture and then the product was extracted twice with 50 ml of ethyl acetate and washed. The aqueous layer thus formed was collected, added with 11 g of anhydrous potassium carbonate and 10 ml of isopropanol, the crystals thus formed were collected by filtration to provide 2.33 g of 3-(2-guanidinothiazol-4-ylmethylthio)propionitrile having a melting point of 127°-128° C.

1. temperaturethe mixture was heated to 110°-120° C. for 4 hours
2. temperatureAfter cooling
3. extractionthe product was extracted twice with 50 ml of ethyl acetate
4. washwashed
5. customThe aqueous layer thus formed
6. customwas collected
7. additionadded with 11 g of anhydrous potassium carbonate and 10 ml of isopropanol
8. customthe crystals thus formed
9. filtrationwere collected by filtration