N-[(Methylamino)carbonyl]-2-(3,3,3-trifluoropropyl)benzenesulfonamide → HCID 10684051, compound

HRID 1165305Notes

Reaction equation

HRID 1165305 reaction equation
[F:1][C:2]([F:20])([F:19])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([NH:14][C:15](NC)=[O:16])(=[O:13])=[O:12]>ClC1C=CC=CC=1>[F:20][C:2]([F:1])([F:19])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([N:14]=[C:15]=[O:16])(=[O:13])=[O:12]

Participants

3

Reactant 1

HCID 15270894N-[(Methylamino)carbonyl]-2-(3,3,3-trifluoropropyl)benzenesulfonamide

Product 1

HCID 10684051HCID 10684051, compound

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

40.3 g of N-[2-(3,3,3-trifluoropropyl)-phenylsulfonyl]-N'-methylurea are suspended in 700 ml of chlorobenzene, and dried by the azeotropic distilling off of about 150 ml of solvent. There are then introduced at 120°-130° C. 71 g of phosgene in the course of 90 minutes. The yield after complete concentration of the formed solution by evaporation is 37.3 g of 2-(3,3,3-trifluoropropyl)-phenylsulfonylisocyanate in the form of yellowish oil, which can be directly further reacted.

Workup

  1. customdried by the
  2. distillationazeotropic distilling off of about 150 ml of solvent
  3. additionThere are then introduced at 120°-130° C
  4. customin the course of 90 minutes
  5. customThe yield
  6. concentrationafter complete concentration of the formed solution
  7. customby evaporation

Sources & evidence

ORD record
ord-59071ddf7a2c4eac825c4068da240149
Source dataset
uspto-grants-1990_03
Patent number
US04908467

Reaction notes

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