反应详情

To a solution of 2-(4-acetylphenoxy)propanoic acid (5.08 g, 24.4 mmol) in acetic acid (20 mL) is added purified peracetic acid (16%, 15.80 g, 33.3 mmol) over 30 minutes. The reaction mixture is stirred under reflux at 55° C. to 60° C. and 60-64 mm Hg for 9 hours. The solution is rotovapped and vacuumed to remove the acetic acid. The product obtained is 5.0 g of 2-(4-acetoxyphenoxy)propanoic acid (yield 91%): m.p. 102° C., 1H NMR (CDCl3, delta 1.63 (d, J=7.0 Hz, 3H), 2.26 (s, 3H), 4.85 (q, J=7.0 Hz, 1H), 7.10 (m, 4H).

1. temperatureunder reflux at 55° C. to 60° C.
2. customto remove the acetic acid
3. customThe product obtained