4-Methoxyphenol → HCID 12179184, compound

Participants

Reaction Steps

4-Methoxyphenylalaninate was first prepared by reacting N-benzyloxycarbonyl-(S)-alanine (10.9 g, 0.049 mole) with 4-methoxyphenol and 1,3-dicyclohexylcarbodiimide to give 9.2 g (57%) of N-benzyloxycarbonyl-(S)-alanine 4-methoxyphenyl ester, mp 128°-129° C.; [α]D25 -18.98° (c=0.769, CHCl3); IR (KBr): 3320, 1750 and 1660 cm-1 ; NMR (δ): 1.52 (3H, d, J=7.4 Hz), 3.72 (3H, s), 4.48 (1H, q, J=7.4 Hz), 5.08 (2H, s), 5.36-5.48 (1H, broad, signal disappeared in D2O), 6.68-7.48 (9H, m). Anal. for C18H19NO5 : Calcd: C, 65.65; H, 5,77; N, 4.25. Found: C, 65.74; H, 5.91; N, 4.31.

Provenance & Evidence