反应详情

(R)-N-α-Methylbenzyl-4-vinylbenzamide was prepared as above in Example 1 except 2.5 g (0.017 mole) of 4-vinylbenzoic acid and 2.13 g (0.018 mole) of (R)-α-methylbenzylamine (Aldrich) were used rather than the 2.0 g of 4-allyloxybenzoic acid and 2 g of (S)-1-(1-naphthyl)ethylamine in Example 1. The product was recrystallized from absolute ethanol to give 1.85 g (44%) of white crystals; mp 162°-163° C.; [α]D25 -25.49° (c=0.404, CHCl3); IR (KBr): 3390 and 1640 cm-1 ; NMR (δ): 1.64 (3H, d, J=7.4 Hz); 5.32 (1H, q, J=7.4 Hz); 5.44-5.94 (2H, m); 6.48-6.92 (2H, m), 7.24-7.82 (9H, m). Anal. for C17H17NO: Calcd: C, 81.27; H, 6.77. Found: C, 81.24; H, 6.79.

1. customThe product was recrystallized from absolute ethanol