Pyridine → HCID 19861647, compound

Participants

Reaction Steps

Thionyl chloride (2.0M/CH2Cl2 ; 7.4 mL, 0.015 mol) was added dropwise to a stirred suspension of N'-hydroxy-(3-bromo-2-naphthalenyl)ethanimidamide (3.29 g, 0.012 mol), methylene chloride (125 mL) and pyridine (2.4 mL, 0.03 mol) at 5° C. After 20 minutes at -5° C., the reaction solution was added to ice/H2O. The organic layer was separated, washed with saturated NaCl, dried over MgSO4 and concentrated in vacuo to a slurry (20 mL). Diethyl ether (20 mL) was added and the title compound (1.40 g, yield 36%) was collected (153°-154° C. decomp.).

Provenance & Evidence