Dibutylamine → HCID 19861849, compound

Participants

Reaction Steps

30 g. of 3-(4-cyanomethylphenoxy)propylene oxide were mixed with 133.5 ml dibutylamine and 300 ml methanol and stirred at room temperature for 20 hours. The mixture was concentrated in a rotary evaporator and the residue was taken up in 225 ml of 1 N hydrochloric acid. The acidic solution was extracted with a total of 300 ml of dichloromethane. The dichloromethane phase was discarded. The aqueous phase was mixed with about 70 ml of 4 N caustic soda solution and extracted by shaking with 200 ml dichloromethane. The dichloromethane phase was dried over sodium sulfate. The desiccant was filtered off and the dichloromethane was drawn off with a rotary evaporator.

Provenance & Evidence