Acetic Anhydride → HCID 135965029, compound

HRID 1165424Notes

Reaction equation

HRID 1165424 reaction equation
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[C:5]([OH:9])=[C:4]([CH3:10])[N:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>N1C=CC=CC=1>[C:11]([O:9][C:5]1[C:6](=[O:8])[NH:7][C:2]([NH2:1])=[N:3][C:4]=1[CH3:10])(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1354409884(1H)-Pyrimidinone, 2-amino-5-hydroxy-6-methyl- (9CI)

Product 1

HCID 135965029HCID 135965029, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
25 °C

Procedure

2-Amino-5-hydroxy-6-methyl-4-pyrimidone (0.88 g, prepared as described in Hull, J. Chem. Soc., 2033 (1956)), was treated with pyridine (5 ml) and acetic anhydride (0.5 ml) at 0° C. The reaction mixture was stirred at 25° C. for 18 hours. Filtration provided a white solid (0.64 g). Recrystallization (absolute ethanol) afforded a white crystalline solid (m.p.: 273°-276° C.).

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-4c02ec1cc6d84ed68e513b0abd4f9858
Source dataset
uspto-grants-1990_03
Patent number
US04910204

Reaction notes

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