反应详情

In 140 ml of water was dissolved 18.3 g (0.28 mol) of potassium hydroxide, and thereto were added 25.6 g (0.093 mol) of 4,5-dichloro-2-(4-chlorophenyl)-3(2H)-pyridazinone and 140 ml of ethanol. The reaction mixture was refluxed for 6 hours. After allowing to cool, ethanol was distilled off from the mixture under reduced pressure and then 300 of water was added to the mixture. Insoluble matter was removed by filtration and filtrate was acidified with hydrochloric acid. The solid thus precipitated was taken out by filtration, washed with water, and recrystallized from ethanol to give 11.1 g of the intended compound having melting point (hereinafter referred to as "m.p.") of 270°-271° C.

1. temperatureThe reaction mixture was refluxed for 6 hours
2. temperatureto cool
3. distillationethanol was distilled off from the mixture under reduced pressure
4. addition300 of water was added to the mixture
5. customInsoluble matter was removed by filtration and filtrate
6. customThe solid thus precipitated
7. filtrationwas taken out by filtration
8. washwashed with water
9. customrecrystallized from ethanol