HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 4-chloro-2-(4-chlorophenyl)-5-(4-trifluoromethylbenzyloxy)-3(2H)-pyridazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 4-(Trifluoromethyl)benzenemethanol | HCID 67684 | — |
| Reactant | 4,5-Dichloro-2-(4-chlorophenyl)-3(2H)-pyridazinone | HCID 779402 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-chloro-2-(4-chlorophenyl)-5-(4-trifluoromethylbenzyloxy)-3(2H)-pyridazinone | HCID 14072248 | 59.7% |
Reaction Steps
In 30 ml of N,N-dimethylformamide were dissolved 1.0 g (3.6 m mol) of 2-(4-chlorophenyl)-4,5-dichloro-3(2H)-pyridazinone and 0.64 g (3.6 m mol) of p-trifluoromethylbenzyl alcohol, and thereto was added 0.24 g of powdery potassium hydroxide. The reaction mixture was stirred at room temperature for one day. Then, the procedures in Synthesis Example 2 were repeated to give 900 mg of the intended compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04910201 |
| Source dataset | uspto-grants-1990_03 |
| ORD ID | ord-eeea809c9afa424a8edd70df7048a03e |
| Source note | uspto-grants-1990_03 |