Triethylamine → HCID 86743809, compound

Participants

Reaction Steps

A solution of 3.47 g of 19-mercaptopregn-4-ene-3,20-dione and 4-dimethylaminopyridine in 50 ml of dichloromethane is chilled to 0° C. and treated with 4.2 ml of trifluoroacetic anhydride and 8.4 ml of triethylamine. The ice-bath is removed and the solution allowed to stir for 1 hour. The solution is concentrated. The residue is taken up in ether and washed once with 1N hydrochloric acid, twice with water and once with sodium bicarbonate solution and brine. The resulting solution is dried and concentrated. Recrystallization of the resulting residue from ethyl acetate/hexane provides 19-mercaptopregn-4-ene-3,20-dione trifluoroacetate as white crystals.

Provenance & Evidence