HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-H-epoxybenzazepin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,3,4,5-Tetrahydro-1H-1,5-epoxybenzo[d]azepine oxalate | HCID 14208734 | — |
| Product | 3-H-epoxybenzazepin | HCID 86742305 | 103.8% |
Reaction Steps
The product prepared in Example 19 (3.85 g, 0.15M) was made basic with NaOH, partitioned between H2O and CH2Cl2, and the organic layer dried (Na2SO4) and evaporated to give the 3-H-epoxybenzazepin (2.50 g, 0.015M). This compound was treated with propionic anhydride (10 ml) and allowed to stir for two hours. Excess propionic anhydride was removed in vacuo to give 3-propoxy-epoxybenzazepin as a white solid (3.3 g, 98% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04910198 |
| Source dataset | uspto-grants-1990_03 |
| ORD ID | ord-766f6168eb3642358a1e3f9099485473 |
| Source note | uspto-grants-1990_03 |