Veratrole → (3,4-dimethoxyphenyl)(4-fluorophenyl)methanone

Participants

Reaction Conditions

Reaction Steps

Veratrole (29.3 g) was added, while stirring, to a mixture of aluminum chloride (34 g) and 4-fluorobenzoyl chloride (35 g) which had been cooled to 0° C., and the resulting mixture allowed to stand for 12 hours at room temperature. It was then boiled for 1 hour. The reaction mixture was then decomposed with water/HCl and extracted with chloroform.

Provenance & Evidence