Carbon Dioxide → HCID 54143672, compound

Participants

Reaction Steps

4.7 g of carbonyldiimidazole were added in portions to a solution of 9.4 g of 3-(biphenyl-4-yl)-3-(3,4-dimethoxyphenyl)acrylic acid in 50 ml of anhydrous tetrahydrofuran. After the evolution of CO2 had subsided, 2.5 g of morpholine were added, and the mixture was boiled for 1 hour. After evaporation, the residue was taken up in toluene/water, and the aqueous phase was discarded. The organic phase was washed once more with water, then dried and evaporated. The crude title compound was isolated with a yield of 10.5 g. The crude product was purified on silica gel with toluene/ acetone (9:1). 6.2 g of the title compound were obtained in the form of a yellow resin, Rf: 0.56 ]l (silica gel, toluene/ acetone 7:3).

Provenance & Evidence