反应详情

To a solution of diethyl 1,1-cyclopentane dicarboxylate (2.5 g, 11.68 mol) in EtOH (10 ml) was added dropwise a solution of KOH (654 mg, 11.68 mmol) in EtOH (10 ml) over 1/2 hour. The resulting mixture was stirred at room temperature for 96 hr, concentrated under vacuum, and partitioned between H2O and EtOAc. The aqueous layer was acidified with concentrated HCl and extracted with EtOAc. The EtOAc extracts were washed (brine), dried (Na2SO4), filtered, and concentrated under vacuum to give the product (1.73 g) as a clear oil.

1. concentrationconcentrated under vacuum
2. custompartitioned between H2O and EtOAc
3. extractionextracted with EtOAc
4. washThe EtOAc extracts were washed (brine)
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated under vacuum