HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-(4-Aminocarbonylphenoxy)butanoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Reactant | (4-Hydroxyphenyl)acetamide | HCID 86986 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(4-Aminocarbonylphenoxy)butanoic acid ethyl ester | HCID 53678984 | 60% |
Reaction Steps
A mixture of p-hydroxyphenylacetamide (3.8 g), ethyl 4-bromobutyrate (3.6 ml) and K2CO3 (3.45 g) was stirred for 12 hr in DMF (30 ml). The mixture was diluted with water (100 ml); the solid was filtered and air dried. Crystallization of the solid from ethanol gave 4 g (60%) of the title compound as white crystals; mp 144.5°-145.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04910190 |
| Source dataset | uspto-grants-1990_03 |
| ORD ID | ord-59ae9db9557c46f7ad8a5e92dc7982a7 |
| Source note | uspto-grants-1990_03 |