HCID 2908750, compound → HCID 434308, compound

HRID 1165567Notes

Reaction equation

HRID 1165567 reaction equation
[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH:10]([NH:14]CC2C=CC=CC=2)[C:9]1=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pd]>[NH2:14][CH:10]1[CH2:11][C:12](=[O:13])[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:9]1=[O:22]

Participants

5

Reactant 2

HCID 2908750HCID 2908750, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 434308HCID 434308, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

56.5 g (0.184 mol) of 95% strength 1-benzyl-3-benzylaminopyrrolidine-2,5-dione are dissolved in 700 ml of ethanol and hydrogenated with 2 g of palladium on charcoal (5%) for 4 hours at 70° C. and 60 bar of hydrogen pressure. The catalyst is then filtered off, the filtrate is concentrated, and the residue is dried at 50° C./0.1 mbar. This gives 36.2 g of product with a content of 94%, determined by gas chromatography and corresponding to a yield of 91% of theory. Melting point 74° to 77° C.

Workup

  1. filtrationThe catalyst is then filtered off
  2. concentrationthe filtrate is concentrated
  3. customthe residue is dried at 50° C./0.1 mbar

Sources & evidence

ORD record
ord-b7e7082dc76042c88ebc9b96827e7efe
Source dataset
uspto-grants-1990_03
Patent number
US04910319

Reaction notes

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