Water → 1-Benzyl-3-aminopyrrolidine

Participants

Reaction Steps

34 g (0.9 mol) of lithium aluminum hydride are initially introduced under nitrogen in 500 ml of anhydrous tetrahydrofuran, and 80.8 g (0.4 mol) of 3-amino-1-benzylpyrrolidine-2,5-dione are added dropwise to the mixture as a solution in 400 ml of tetrahydrofuran. The mixture is then refluxed for 20 hours. 34 g of water in 120 ml of tetrahydrofuran, 34 g of 10% strength potassium hydroxide solution and also 136 g of water are added dropwise in succession to the mixture. The solid is filtered off with suction, washed with THF, thoroughly boiled in 250 ml of tetrahydrofuran and again filtered off with suction. The combined filtrates are concentrated in a rotary evaporator, and the residue is distilled under reduced pressure.

Provenance & Evidence