HCID 13730803, compound → HCID 13852386, compound
Reaction equation
[F:1][CH:2]([F:20])[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14](O)=[O:15])[C:8]([C:17]([OH:19])=[O:18])=[CH:7]2>C(OC(=O)C)(=O)C>[F:1][CH:2]([F:20])[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]1[C:14]([O:18][C:17](=[O:19])[C:8]1=[CH:7]2)=[O:15]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 85 °C
Procedure
A mixture of 6-difluoromethoxyquinoline-2,3-dicarboxylic acid (0.14 mol) in 125 mL acetic anhydride is heated at 85° C. for one-half hour and then at 100° C. for one hour. The mixture is cooled, then filtered and the solids washed with ether to give 6-difluoromethoxyquinoline-2,3-dicarboxylic acid anhydride mp 157.5°-158.5° C.
Workup
- temperatureThe mixture is cooled
- filtrationfiltered
- washthe solids washed with ether
Sources & evidence
- ORD record
- ord-0d3215341d0a447e9935b327b0e7c4ef
- Source dataset
- uspto-grants-1990_03
- Patent number
- US04911753
Reaction notes
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