HCID 15017241, compound → HCID 15017242, compound

Participants

Reaction Conditions

Reaction Steps

A solution containing 4.7 g N-[1,2-dimethyl-1-(thiocarbamoyl)propyl]-m-toluamide in 75 mL THF and 35 mL 10% NaOH is heated at 65° C. for 18 hours. The THF is removed in vacuo and the pH of the cooled residue adjusted to 3 with concentrated H2SO4. The product is extracted into CH2Cl2, the extract washed with brine, dried and concentrated to give a yellow solid. This is recrystallized from acetonitrile to give analytically pure 4-isopropyl-4-methyl-2-m-tolyl-2-imidazolin-5-thione, mp 122°-123° C.

Provenance & Evidence