Acetyl isothiocyanate → HCID 14837973, compound

HRID 1165773Notes

Reaction equation

HRID 1165773 reaction equation
[C:1]([N:4]=[C:5]=[S:6])(=[O:3])[CH3:2].[CH2:7]([N:11]1[C:16]([NH:17][NH2:18])=[CH:15][C:14](=[O:19])[N:13]([CH2:20][CH2:21][CH3:22])[C:12]1=[O:23])[CH2:8][CH2:9][CH3:10]>O1CCOCC1>[C:1]([NH:4][C:5](=[S:6])[NH:18][NH:17][C:16]1[N:11]([CH2:7][CH2:8][CH2:9][CH3:10])[C:12](=[O:23])[N:13]([CH2:20][CH2:21][CH3:22])[C:14](=[O:19])[CH:15]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 128851Acetyl isothiocyanateHCID 13824276HCID 13824276, compound

Product 1

HCID 14837973HCID 14837973, compoundYield 123.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Acetylisothiocyanate(4.8 g) was added dropwise to a stirred solution of 1-butyl-6-hydrazino-3-propylpyrimidine-2,4(1H,3H)-dione(8.0 g) in dioxane(100 ml). The mixture was stirred for 3 hours at room temperature, then precipitating crystals were collected by filtration. Recrystallization from aqueous alcohol gave colorless crystals (14 g, 94%), m.p. 149°-152° C.

Workup

  1. customprecipitating crystals
  2. filtrationwere collected by filtration
  3. customRecrystallization from aqueous alcohol

Sources & evidence

ORD record
ord-88a98373fe79428eb172b1f7e6ae546f
Source dataset
uspto-grants-1990_03
Patent number
US04912104

Reaction notes

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