Oxalic acid dihydrate → HCID 178516987, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,0 g (4,2 mmol) 1,2-diamino-5-bromonaphthalene and 1,2 g (9,5 mmol) oxalic acid dihydrate in 20 ml 4 N hydrochloric acid was refluxed for 2,5 h. After cooling to 25° C., the precipitate was filtered off and washed with water. The crude product was dissolved in 200 ml 2 N sodium hydroxide, and reprecipitated with 4N hydrochloric acid (to pH 1-2) to give 820 mg (67%) of pure 7-bromo-2,3-dihydroxybenzo(f)quinoxaline, m.p. >300° C.1H NMR (DMSO-d6 ): 8,6 (1H,d), 7,8 (1H,d), 7,7 (1H,d), 7,4 (1H,d), 7,3 (1H,d).

Provenance & Evidence