Ammonia → HCID 14582066, compound

Participants

Reaction Steps

3.25 g (8.9 mMol) of the compound of example 1 and 10 g of pyridine hydrochloride are heated for 3 hours to 190° C., then taken up in water after cooling, rendered basic with conc. ammonia, and extracted three times with methylene chloride. Flash-chromatography with ethyl acetate/hexane 1:5 yields the title compound as colorless crystals. Recrystallization from ether/pentane yields an analysis-pure product: M.p.: 157°-158° C.

Provenance & Evidence