Sodium borohydride → HCID 19861148, compound

HRID 1165836Notes

Reaction equation

HRID 1165836 reaction equation
[BH4-].[Na+].[N:3]1([CH:8]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=2[Cl:26])[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[O:10])[CH:7]=[N:6][CH:5]=[N:4]1>CO>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([CH:9]([OH:10])[CH:8]([N:3]2[CH:7]=[N:6][CH:5]=[N:4]2)[CH2:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=2[Cl:26])=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 19861150HCID 19861150, compound

Product 1

HCID 19861148HCID 19861148, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium borohydride (0.42 g) was added in small portions to 2-(1,2,4-triazol-1-yl)-2-(2',4'-dichlorobenzyl)-4'-chloroacetophenone (4.2 g) in methanol (40 ml). When the effervescence ceased, the mixture was refluxed for 1 hour, cooled to room temperature and the methanol removed at the water pump. The residue was acidified with 1N-hydrochloric acid to give a solid which was filtered and washed. Recrystallisation from ethanol/water gave white crystals of the title compound (yield 80%).

Workup

  1. temperaturethe mixture was refluxed for 1 hour
  2. customthe methanol removed at the water pump
  3. customto give a solid which
  4. filtrationwas filtered
  5. washwashed
  6. customRecrystallisation from ethanol/water

Sources & evidence

ORD record
ord-b64923a9957749dc8abedaa19538e385
Source dataset
uspto-grants-1990_03
Patent number
US04912121

Reaction notes

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