反应详情

To a solution of 4-chloro-3,5-diaminobenzonitrile (3.34 g) in pyridine (60 ml) is added dropwise methoxyacetyl chloride (4.0 ml) at room temperature. The mixture is stirred at room temperature for 2 hours, and thereafter, pyridine is distilled off under reduced pressure. To the residue is added water, and the resulting solid substance is separated by filtration and washed with water. The resulting crude crystals are recrystallized from ethanol to give the title compound (5.1 g) having the following physical properties.

1. distillationpyridine is distilled off under reduced pressure
2. additionTo the residue is added water
3. customthe resulting solid substance is separated by filtration
4. washwashed with water
5. customThe resulting crude crystals are recrystallized from ethanol