HCID 14677718, compound → HCID 14677730, compound

HRID 1165958Notes

Reaction equation

HRID 1165958 reaction equation
CC(C1C=CC(CC(=O)CC)=CC=1)(C)C.C(O)(=O)/C=C\C(O)=O.C1C2CCC3C=CC=CC=3C(=[C:39]3[CH2:44][CH2:43][N:42]([CH2:45][CH2:46][CH2:47][C:48]([C:50]4[CH:55]=[CH:54][C:53]([C:56]([CH3:59])([CH3:58])[CH3:57])=[CH:52][CH:51]=4)=[O:49])[CH2:41][CH2:40]3)C=2C=CC=1.[CH:60]1[C:70]2[CH:69]([OH:71])[C:68]3[CH:72]=[CH:73][CH:74]=[CH:75][C:67]=3[CH2:66][O:65][C:64]=2[CH:63]=[CH:62][CH:61]=1>CCOCC>[CH3:59][C:56]([C:53]1[CH:54]=[CH:55][C:50]([CH:48]([OH:49])[CH2:47][CH2:46][CH2:45][N:42]2[CH2:41][CH2:40][CH:39]([C:69]3([OH:71])[C:68]4[CH:72]=[CH:73][CH:74]=[CH:75][C:67]=4[CH2:66][O:65][C:64]4[CH:63]=[CH:62][CH:61]=[CH:60][C:70]3=4)[CH2:44][CH2:43]2)=[CH:51][CH:52]=1)([CH3:57])[CH3:58]

Participants

5

Reactant 3

HCID 14677718HCID 14677718, compoundHCID 22727883HCID 22727883, compoundHCID 62620032HCID 62620032, compound

Product 1

HCID 14677730HCID 14677730, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

By procedures essentially the same as those described in Example 2, and by substituting 4-[4-(6,1]-dihydro-11-hydroxydibenz[b,e]oxepin-11-yl)-1-piperidinyl]-1-[4-(1,1-dimethylethyl)phenyl]butanone for 4-[4-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinyl]-1-[4-(1,1-dimethylethyl)phenyl]-1-butanone maleate; the corresponding 11-[1-[4-[4-(1,1-dimethylethyl)phenyl]-4-hydroxybuty]]-4-piperidinyl]-6,11-dihydrodibenz[b,e]oxepin-11-ol, mp 135°-137° C. and 162-165° C. (ether), was prepared.

Sources & evidence

ORD record
ord-1f5b51bd082742ec9e9c78d17e9ed300
Source dataset
uspto-grants-1990_03
Patent number
US04912222

Reaction notes

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