Aluminum(III) Chloride → HCID 18638379, compound

HRID 1165966Notes

Reaction equation

HRID 1165966 reaction equation
[Cl-].[Cl-].[Cl-].[Al+3].[Cl:5][C:6]1[CH:22]=[CH:21][CH:20]=[CH:19][C:7]=1[C:8]([N:10]1[CH2:17][C@@H:16](F)[CH2:15][C@H:11]1[C:12]([OH:14])=[O:13])=[O:9]>C1C=CC=CC=1>[Cl:5][C:6]1[CH:22]=[CH:21][CH:20]=[CH:19][C:7]=1[C:8]([N:10]1[CH2:17][C@H:16]([C:6]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:7]=2)[CH2:15][C@H:11]1[C:12]([OH:14])=[O:13])=[O:9]

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 14750329HCID 14750329, compound

Product 1

HCID 18638379HCID 18638379, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A suspension of aluminum trichloride (100 mg, 0.75 mmole) in benzene (3.7 ml) was stirred under argon and treated with (cis)-1-o-chloro- benzoyl-4-fluoro-L-proline (60 mg, 0.22 mmole). After stirring overnight, the reaction was cooled, quenched with 1N HCl and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried and concentrated in vacuo. The residue consisted of

Workup

  1. stirringAfter stirring overnight
  2. temperaturethe reaction was cooled
  3. customquenched with 1N HCl
  4. extractionextracted with ethyl acetate
  5. washThe combined organic extracts were washed with brine
  6. customdried
  7. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-1d1a11d1176c4575b686d741b39aa9c9
Source dataset
uspto-grants-1990_03
Patent number
US04912231

Reaction notes

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