反应详情

温度

150 °C

To 6,05 g (40 mMol) 6-fluoro-1,2,3,4-tetrahydroquinoline in 20 ml acetone, 5.9 g (48 mMol) of propane sultone dissolved in 20 ml acetone are added dropwise for a period of 40 minutes at 50° to 60° C. After 24 hours of refluxing and again after 48 hours a further 5.9 g of propane sultone are added. After a total of 60 hours of refluxing, the reaction mixture is concentrated by evaporation and the volatile components are removed in high vacuum (0.01 torr) by heating to about 150° C. The residue is recrystallized from 115 ml methanol.

1. additionare added dropwise for a period of 40 minutes at 50° to 60° C
2. additionare added
3. temperatureAfter a total of 60 hours of refluxing
4. concentrationthe reaction mixture is concentrated by evaporation
5. customthe volatile components are removed in high vacuum (0.01 torr)
6. customThe residue is recrystallized from 115 ml methanol