HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophosgene → HCID 22340996, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | 4-chloro-2-fluoro-5-(2-pyrimidinyloxy)aniline | HCID 11447802 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 22340996 | HCID 22340996 | — |
Reaction Steps
4-Chloro-2-fluoro-5-(2-pyrimidinyloxy)benzenamine (1.0 g) was dissolved in anhydrous ethyl acetate (50 ml) and thiophosgene (0.59 g) was slowly added to the stirred solution. The mixture was heated at reflux for 2 hr. Evaporation of the solvent afforded 2-(2-chloro-4-fluoro-5-isothiocyanatophenoxy)pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06613718B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-36e7756d243443f2bebc853a2dca8e46 |
| Source note | uspto-grants-2003_09 |