3,4-Dimethoxy-6-nitrobenzamide → 2-Amino-4,5-dimethoxybenzamide

HRID 1166148Notes

Reaction equation

HRID 1166148 reaction equation
[N+:1]([C:4]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7])([O-])=O.[H][H]>O.[Pt](=O)=O>[NH2:1][C:4]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7]

Participants

4

Reactant 2

HCID 27361933,4-Dimethoxy-6-nitrobenzamideHCID 178418361HCID 178418361, compound

Product 1

HCID 108672362-Amino-4,5-dimethoxybenzamide

Reagents, catalysts & solvents 1

HCID 11139377Platinum dioxide monohydrateCatalyst

Procedure

A suspension of 28 g of 2-nitro-4,5-dimethoxybenzamide was hydrogenated under normal pressure in the presence of 1.5 g of platinum dioxide hydrate until hydrogen was no longer absorbed. The catalyst was filtered off with suction, the filtrate was evaporated and the residue was dried under reduced pressure. Yield: 24.1 g. M.p.: 147° C.

Workup

  1. customwas no longer absorbed
  2. filtrationThe catalyst was filtered off with suction
  3. customthe filtrate was evaporated
  4. customthe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-03213f55a4864e9fa20e2a1b3b4dc200
Source dataset
uspto-grants-2003_09
Patent number
US06613772B1

Reaction notes

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