反应详情

温度

150 °C

A mixture of 2.0 g of 2-(4-chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline and 5.0 g of N-benzylpiperazine was heated at 150° C. for 1 h. After cooling, 20 ml of ice water were added and the mixture was extracted with ethyl acetate. The organic phase was dried over sodium sulfate and concentrated. The oily crude product thus obtained was recrystallized from isopropanol. Yield: 1 g. M.p.: 150° C.

1. temperatureAfter cooling
2. extractionthe mixture was extracted with ethyl acetate
3. dry with materialThe organic phase was dried over sodium sulfate
4. concentrationconcentrated